Disease Information:Malaria ended the lives of approximately 450,000 people in 2015, most of whom were children under the age of five. The disease causes symptoms such as accelerated heart rate, chills, fatigue, and fever which can be fatal to children. Majority of malaria cases come about through infection by Plasmodium falciparum, a protozoan parasite that is commonly transmitted through mosquitoes. Resistance to chloroquine, an anti-parasitic drug widely used to treat malaria, has caused a demand for the discovery and production of new drugs to combat the disease.
NCBI Gene # or RefSeq#:Gene ID: 812093
Protein ID (NP or XP #) or Wolbachia#: Accession: AAA65930.1
Organism: P. falciparum Strain: 3D7
Etiologic Risk Group: 2
Disease Information: Malaria ended the lives of approximately 450,000 people in 2015, most of whom were children under the age of five. The disease causes symptoms such as accelerated heart rate, chills, fatigue, and fever which can be fatal to children. Majority of malaria cases come about through infection by Plasmodium falciparum, a protozoan parasite that is commonly transmitted through mosquitoes. Resistance to chloroquine, an anti-parasitic drug widely used to treat malaria, has caused a demand for the discovery and production of new drugs to combat the disease.
Link to TDR Targets page (if present): N/A
Link to Gene Database page: NCBI; PlasmoDB
Essentiality of this protein: Essential in pentose phosphate pathway and glutathione metabolism
Is it a monomer or multimer as biological unit?: two identical monomers
Complex of proteins?: No, dimer of two identical monomers
Druggable Target: .2 in //L. major//
EC#: 1.1.1.49
BRENDA EC# page: http://www.brenda-enzymes.info/enzyme.php?ecno=1.1.1.49
Enzyme schematic of glucose-6-phosphate-dehydrogenase from BRENDA.
Enzyme Assay information:
Structure (PDB or Homology model)
BLASTP pairwise alignment:
-- Closest PDB# For Homology Model option: 2BH9
---- Query Coverage: 73%
---- Max % Identities: 35%
---- % Positives: 51%
---- Chain used for homology: N/A
Current Inhibitors: 94
Expression Information: PubMed; BRENDA
Purification Method: affinity column
Image of protein (for human 2BH9, G6PD not in PDB):
Amino Acid Sequence: MNNYQNNYIYNEKTLDFINNDQDNDNLKYLKEYVYFTTTNQFDVRKRITVSLNLLANASSKIFLLNSKDK
LDLWKNMLIKSYIEVNYNLYPATYLIDTSCTNENVNINNNNNNNNKNKNNYCYSNTTVISCGYENYTKYI
EEIYDSKYALSLYSNSLNKEELLTIIIFGCSGDLAKKKIYPALFKLFCNNSLPKDLLIIGFARTVQDFDT
FFDKIVIYLKRCLLCYEDWSISKKKDLLNGFKNRCRYFVGNYSSSESFENFNKYLTTIEEEEAKKKYYAT
CYKMNGSDYNISNNVAEDNISIDDENKTNEYFQMCTPKNCPDNVFSSNYNFPYVINSILYLALPPHIFIS
TLKKIIKKNCLNSKGTDKILLEKPFGNDLDSFKMLSKQILENFNEQQIYRIDHYLGKDMVSGLLKLKFTN
TFLLSLMNRHFIKCIKITLKETKGVYGRGQYFDPYGIIRDVMQNHMLQLLTLITMEDPIDLNDESVKNEK
IKILKSIPSIKLEDTIIGQYEKAENFKEDENNDDESKKNHSYHDDPHIDKNSITPTFCTCILYINSINWY
GVPIIFKSGKGLNKDICEIRIQFHNIMGSSDENMNNNEFVIILQPVEAIYLKMMIKKTGCEEMEEVQLNL
TVNEKNKKINVPEAYETLLLECFKGHKKKFISDEELYESWRIFTPLLKELQEKQVKPLKYSFGSSGPKEV
FGLVKKYYNYGKNYTHRPEFVRKSSFYEDDLLDINY
Length of your protein in Amino Acids: 736 aa
Molecular Weight: 86358.6 Da
Molar Extinction coefficient of your protein at 280 nm wavelength:99115M^-1 cm^-1
TMpred graph Image (http://www.ch.embnet.org/software/TMPRED_form.html).
CDS Gene Sequence (paste as text only): ATGGATTATGAGAATTTTGTAAAAAGTGCAGAAGAAATAAATAATTTACACAATGTAAATTATTTGGAAA
CAAAAGACCTGAATGATTTTAATTGGAAAGCAGCTTATTATATATGTAAAGAAATATATGATAAGCAACA
AATTAATAAAGATGGTTATGTTGTGATAGGTTTATCGGGAGGTCGAACTCCGATAGATGTTTATAAAAAT
ATGTGTTTAATTAAAGACATTAAGATAGATAAATCTAAATTAATATTTTTTATTATTGATGAAAGGTATA
AAAGTGATGATCATAAATTTAGTAATTATAATAATATAAAATTTTTATTTCATAATTTAAATATAAATGA
AAAAGAACAATTATATAAACCTGACACTACCAAAAGTATTGTAGATTGTATATTAGATTATAATGACAAA
ATAAAAATAATGATAGAGAAATATAAAAAAGTTGATATAGCAATATTAGGTATGGGTAGTGATTTCCATA
TTGCCAGTTTATTTCCAAATATATTTTATAATATATATATGAATAACTATCAAAATAATTATATATATAA
TGAAAAAACATTAGATTTTATAAATAATGATCAAGATAATGATAATTTAAAATATTTGAAAGAATATGTA
TATTTTACGACAACAAATCAATTTGATGTTAGGAAAAGAATTACAGTATCTTTAAATTTATTAGCTAATG
CATCAAGTAAAATATTTTTATTAAATTCTAAAGACAAATTAGATTTATGGAAAAATATGTTGATTAAATC
ATATATTGAAGTGAATTATAATTTATATCCAGCTACTTATTTAATAGATACATCATGCACCAACGAAAAT
GTTAATATTAACAATAACAACAATAATAATAATAAGAATAAGAATAATTATTGTTATAGTAATACCACTG
TTATATCTTGTGGTTATGAAAATTATACAAAATCTATTGAAGAAATTTATGATTCTAAATATGCTCTATC
TCTTTATTCTAATAGTTTGAATAAAGAAGAATTATTAACTATAATAATTTTTGGCTGTTCAGGTGATTTA
GCCAAAAAAAAAATATATCCAGCTTTATTTAAATTATTTTGTAATAATTCCTTACCAAAAGATTTATTAA
TCATTGGATTTGCTAGAACAGTTCAAGATTTCGATACATTTTTTGATAAAATAGTTATATATTTAAAACG
ATGTTTATTATGTTATGAAGATTGGTCTATATCAAAAAAGAAGGATCTTTTAAATGGTTTTAAAAATAGG
TGTCGATATTTTGTTGGTAATTATTCGTCTTCAGAAAGTTTTGAAAATTTTAATAAATATTTAACAACTA
TTGAAGAAGAAGAAGCAAAAAAAAAATATTATGCAACATGTTATAAAATGAATGGTTCAGATTATAATAT
ATCAAATAATGTTGCAGAGGATAATATTAGTATAGATGATGAAAATAAAACAAATGAATATTTTCAAATG
TGTACTCCAAAAAATTGCCCTGATAATGTATTTTCATCAAATTATAATTTTCCATATGTTATAAATCGTA
TGTTATATTTAGCATTACCTCCACATATATTTGTTAGTACTTTAAAAAATTATAAAAAAAATTGTTTAAA
TAGTAAAGGCACTGATAAAATATTACTAGAAAAACCATTTGGAAATGATTTAGATTCATTTAAAATGTTA
TCAAAACAAATATTAGAGAATTTTAATGAACAACAAATATATAGAATAGATCATTATTTGGGTAAGGATA
TGGTTTCAGGATTGTTGAAATTAAAATTTACAAATACATTTTTATTATCTTTAATGAATAGACATTTTAT
AAAATGTATTAAAATTACTCTTAAAGAAACTAAAGGTGTATATGGTAGAGGACAATATTTTGATCCCTAT
GGTATTATTAGAGATGTTATGCAAAATCATATGTTACAATTATTAACATTAATAACTATGGAAGATCCTA
TAGATTTAAATGATGAATCTGTAAAAAATGAGAAAATAAAAATTCTTAAATCAATTCCTTCGATCAAATT
AGAAGATACTATTATTGGACAATATGAAAAAGCTGAAAATTTTAAAGAAGATGAAAATAATGATGATGAA
TCGAAAAAAAATCATAGTTATCATGATGATCCACATATAGATAAAAATTCGATTACTCCAACATTTTGTA
CATGTATCTTATATATTAATTCAATTAATTGGTATGGTGTACCAATCATTTTTAAATCTGGAAAAGGTCT
GAATAAAGATATATGTGAAATACGTATACAATTCCATAATATTATGGGGTCGTCTGATGAAAATATGAAT
AATAATGAATTTGTTATTATATTACAACCTGTTGAAGCTATATACCTAAAAATGATGATTAAAAAAACGG
GTTGTGAAGAAATGGAAGAAGTACAATTAAACCTAACAGTGAATGAGAAAAATAAAAAAATTAATGTACC
AGAAGCATATGAAACATTACTCTTAGAATGTTTTAAAGGACATAAAAAAAAATTCATCTCAGACGAGGAA
TTGTATGAATCATGGAGAATATTTACTCCTTTACTTAAGGAACTCCAGGAAAAACAAGTCAAGCCTCTTA
AATATTCTTTTGGATCATCAGGCCCTAAAGAGGTATTTGGACTTGTCAAAAAATATTACAATTATGGTAA
AAATTATACGCACAGACCTGAGTTTGTTAGAAAATCCTCTTTTTATGAAGACGATTTGTTAGATATTAAT
TGATATATGTATATATTTAAATTAACAAATTAACACCCAATGAATATGAAAATAATATATATATATATAT
ATATATTATATGATTGTTTAGTATATTATTACCTATCTTTTATAAGATAACATAAATGTATATATTATGA
CATATATATATATATATATATATTATTTCACTTATCTGCCCACGAACTTTATTTTTGTTTTAAAATTCTA
GTATAATTAAATAAAAGAAAATATTTGGAACAATTTGCATTTTTTATGTATAAATAAAATTTATATAATA
ATATACTTTCATACTTACTTTTTATTTTATTTTATTTTATTTATTTTTTAAATGTCTATTATATATACAT
ATAAATGCGTTTTCAAATAAATAATAAAAACCCATGTTTAACTAATAATATTACAAA
GC% Content for gene:
CDS Gene Sequence (codon optimized) - copy from output of Primer Design Protocol (paste as text only):
GC% Content for gene (codon optimized):